James Joseph Cheetham, Ph.D.
Department of Biology
College of Natural Sciences
1125 Colonel by Drive
Ottawa, Ontario, Canada
Phone: (613) 520-2600 Ext. 3867
Fax: (613) 520-2569
1983-1987. McMaster University, Hamilton, ON, Canada.
B.Sc., Biochemistry, Thesis: Calorimetric studies of membrane
1987-1993. McMaster University, Hamilton, ON, Canada
Ph.D. in Biochemistry, Thesis: The effects of bilayer stabilization
on membrane fusion in model and biological systems. Advisor: Dr. Richard
2001. Universities of British Columbia, New Brunswick and Toronto.
Certificate in Bioinformatics, Canadian Genetic Diseases Network.
1993-1996. Postdoctoral Fellow, Laboratory of Molecular and
Cellular Neuroscience, The Rockefeller University, New York, NY. Advisor:
Dr. Paul Greengard, Nobel Laureate 2000.
surface plasmon resonance studies of protein-protein interactions
cloning, expression and purification of recombinant proteins
1996-2000. Assistant Professor, Department of Biology, Carleton
Ottawa, ON Canada.
biochemical and biophysical studies of protein-protein and protein-lipid
applications of massively parallel computing in bioinformatics
2000-present. Associate Professor, Department of Biology, Carleton
Ottawa, ON Canada.
biochemical and biophysical studies of protein-protein and protein-lipid
2000-present. Guest Investigator, Steacie Institute for Molecular
Sciences, National Research
Council of Canada, Ottawa, ON Canada.
atomic force and near-field microscopy of protein-lipid interactions
2003. Guest Lecturer, University of Aveiro, Aveiro, Portugal.
Biological sequence analysis.
Research efforts in my laboratory are aimed at understanding the structure
and function of biological membranes. We use liposomes and synaptic
vesicles as a model systems for these studies.
We are trying to understand the physicochemical behavior of proteins
and lipids in membranes. We have found that the binding of the synaptic
vesicle protein, synapsin I is modulated by the lipid packing within
model membranes. Cells can control the lipid packing in their membranes
by metabolically altering the lipid composition. To determine the effect
of lipid composition on synapsin binding, we liposomes, monomolecular
films and atomic force microscopy, to investigate the effects of phospholipid
composition. Through such studies, we are obtaining a better understanding
of the physicochemical parameters that affect the interaction of soluble
proteins with membranes.
We use a variety of modern approaches that bridge biophysics, biochemistry,
molecular biology and bioinformatics. Included are cloning and expression
technologies that involve site-directed mutagenesis and recombinant
protein purification and characterization as well as model membrane
production and characterization. Methodologies include fluorescence
spectroscopy, monolayer film balance techniques, atomic force microscopy
and various types of chromatography.
Research efforts in this area include:
Optimization of experimental design: http://cns0.carleton.ca/~jcheetha/pareto
Parallel Clustal with Minimum Vertex Cover Optimization: (with Frank
Database of peripheral membrane proteins (in progress).
Murray, J., Cuccia, L., Ianoul, A., Cheetham, J.J. and
Johnston, L.J. (2004) Imaging the Selective
Binding of Synapsin to Anionic Membrane Domains, ChemBioChem, 5, 1-7.
Hurley, S.L., Brown, D.L. and Cheetham, J.J. (2004) Cytoskeletal Interactions
of Synapsin I in
Non-Neuronal Cells, Biochem. Biophys. Res. Comm., 317, 16-23.
Cheetham, J.J., Murray, J., Ruhkalova, M., Cuccia, L., McAloney, R.,
Ingold, K.U. and Johnston,
L.J. (2003) Interaction of synapsin I with membranes, Biochem. Biophys.
309, 823 -829.
Cheetham, J.J., Dehne, F., Rau-Chaplin, A., Stege, U. and Taillon,
P.J. (2003) Solving Large FPT
Problems on Course Grained Parallel Machines, Journal of Computer and
Cheetham,J.J., Dehne, F., Pitre, S., Rau-Chaplin, A.,
and Taillon, P.J. (2003) Parallel CLUSTAL W For PC Clusters, to appear
in Proc. International Conference on Computational Science and Its Applications
(ICCSA 2003), Montreal, Canada, May 18-21, 2003.
Cheetham, J.J., Dehne, F., Rau-Chaplin, A., Stege, U.,
and Taillon,P. J., (2003) A Parallel FPT Application For Clusters, Proc.
3rd IEEE/ACM International Symposium on Cluster Computing and the Grid
Cheetham, J.J., Weber T., Hilfiker-Rothenfluh, S., Benfenati, F., Brunner,
J., Czernik, A.J. and Greengard, P. (2001) Identification of Domain
C Peptide Sequences of Synapsin I that Insert into Lipid Membranes,
Biochemical J., 354, 57-66.
McManus, G., Buchanan, G., Jarrel, H., Epand, R.M., Epand, R. and Cheetham,
J.J. (2001) Membrane Perturbing Properties of Sucrose Polyesters, Chem.
Phys. Lipids, 109, 185- 202.
Cross, A.R., McPhee, D., Stevens, D., McDonald, M., Cheetham, J.J.,
and Santyr, G.E. (2000) Hyperpolarized Xenon Relaxation Times in Perfluorocarbon
Emulsion and Plasma Mixtures, Proceedings of the World Congress on Medical
Boudreau, R., Carmody, G. and Cheetham, J.J. (1999) Pareto Analysis
of Paleontological Data: A New Method of Weighing Variable Importance,
Paleontologica Electronica, 2, 1-6.
Zambrano, N., Buxbaum, J.D., Minopoli, G., Fiore, F., De Candia, P.,
De Renzis, S., Faraonio, R., Sabo, S., Cheetham, J.J., Sudol, M. and
Russo, T. (1997) Interaction of the Phosphotyrosine Interaction/Phosphotyrosine
Binding Domains of Fe65 with Wild-Type and Mutant Alzheimer's ß-Amyloid
Precursor Proteins, J. Biol. Chem., 272, 6399-6405.
Desdouits, F., Cheetham. J.J., Huang, H.-B., Kwon, Y.-S., da Cruz e
Silva, E.F., Denefle, P., Ehrlich, M.E., Nairn, A.C., Greengard, P.
and Girault, J.-A. (1995) Mechanism of Inhibition of Protein Phosphatase
1 by DARPP-32: Studies with Recombinant DARPP- 32 and Synthetic Peptides
(1995) Biochem. Biophys. Res. Comm., 206, 652-658.
Van Gorkom, L.C.M., Cheetham, J.J. and Epand, R.M., Ganglioside GD1a
Generates Domains of High Curvature in Phosphatidylethanolamine Liposomes
as Determined by Solid State 31P NMR Spectroscopy, (1995) Chem. Phys.
Lipids, 76, 103-108.
Cheetham, J.J., Nir, S., Johnson, E., Flanagan, T.D. and Epand, R.M.,
The Effects of Membrane Physical Properties on the Fusion of Sendai
Virus with Human Erythrocyte Ghosts and Liposomes: Analysis of the Kinetics
and Extent of Fusion (1994) J. Biol. Chem., 269, 5467- 5472.
Epand, R.M., Cheetham, J.J., Epand, R.F., Yeagle, P., Richardson, C.,
Rockwell, A. and DeGrado, W.F., Peptide Models for the Membrane Destabilizing
Actions of Viral Fusion Proteins, (1992) Biopolymers, 32, 309-314.
Cheetham, J.J., Chen, R.J.B. and Epand, R.M., Interaction of Calcium
and Cholesterol Sulphate Induces Membrane Destabilization and Fusion:
Implications for the Acrosome Reaction (1990) Biochim. Biophys. Acta,
Cheetham, J.J., Andrews, M, Epand, R.M. and Flanagan, T.D., Cholesterol
Sulphate Inhibits the Fusion of Sendai Virus to Biological and Model
Membranes (1990) J. Biol. Chem., 265, 12404-12409.
Cheetham, J.J., Epand, R.M., Bach, D. and Wachtel, E., Role of the
Stereochemistry of the Hydroxyl Group of Cholesterol and the Formation
of Nonbilayer Structures in Phosphatidylethanolamines (1989) Biochemistry,
Epand, R.M., Stafford, A.R., Cheetham, J.J., Bottega, R. and Ball,
R.H., The Relationship Between the Bilayer to Hexagonal Phase Transition
Temperature in Membranes and Protein Kinase C Activity (1988) Biosci.
Rep., 8, 49-54.
Epand, R.M., Cheetham, J.J. and Raymer, K.E., Acid-Induced Fusion of
Liposomes: Studies with 2,3-Seco-5a-Cholestan-2,3-Dioic Acid (1988)
Biochim. Biophys. Acta, 940, 85-92.
Cheetham, J.J. and Epand, R.M., Comparison of the Interaction of the
Anti-Viral Chemotherapeutic Agents Amantadine and Tromantadine with
Model Phospholipid Membranes (1987) Biosci. Rep., 7, 225-230.
Papers Presented at Scientific Meetings
Johnston, L., Ianoul, A., Murray, J., and Cheetham, J.J. (2003) Near-Field
Scanning Optical Microscopy Studies of Proteins in Model Membranes,
Biophysical Society 47th Annual General Meeting, March 1-5, 2003, San
Antonio, Texas, USA.
Cheetham, J.J., Murray, J., Dulubova, M., Cuccia, L. and Johnston,
L. (2002) Stabilization of Membranes by Synapsin I. Membrane Biology
Meeting, University of Montreal, Montreal, Quebec, Canada.
Cross, A.R., Santyr, G.E., McPhee, D., Wallace, J., Cheetham, J.J.
and Cron, G. (2001) Effects of Dilution and Oxygenation on T1 of Hyperpolarized
129 Xe in Perfluorocarbon Emulsions, International Society for Magnetic
Resonance Imaging, Edinburgh, Scotland.
Hurley, S., Brown, D. and Cheetham, J.J. (2000) Synapsin I-Green Fluorescent
Fusion Protein Binds to Actin in Non-Neuronal Cells, American Association
of Cell Biology, Annual Meeting, San Francisco, CA.
Cross, A.R., McPhee, D., Stevens, D., McDonald, M., Cheetham, J.J.
and Santyr, G.E., (2000) Hyperpolarized 129Xe T1 Relaxation in Perfluorocarbon
Emulsion and Plasma Mixtures, American Society for Magnetic Resonance
Meeting, Chicago IL, USA.
Hurley, S., Brown, D. and Cheetham, J.J. (1999) Expression of Synapsin
I-Green Fluorescent Fusion Protein in Non-Neuronal Cells, Ottawa Life
Sciences National Conference and Exhibition, Ottawa, Canada.
Hurley, S., Cull, J., Peel, M. and Cheetham, J.J. (1998) A Continuous
Process for Production of Liposmes, Ottawa Life Sciences National Conference
and Exhibition, Ottawa, Canada.
Hurley, S.,Cull, J., Peel, M. and Cheetham, J.J. (1998) Disruption
of Yeast using High Pressure Homogenization, Ottawa Life Sciences National
Conference and Exhibition, Ottawa, Canada.
Hughes, S.R., Watanabe, T., Buxbaum, J.D., Cheetham, J.J., Greengard,
P., Riedel, N.G. and Sahasrabudhe, S.R. ß-Amyloid Peptide Interacts
with a-Tubulin In Vivo (1996) Society for Neuroscience, 26th. Annual
Meeting, Washington, DC.
Cheetham, J.J., McPherson, P.S., Wagg, J., Czernik, A.J., E.F. da Cruz
e Silva, De Camilli, P., Schlessinger, J. and Greengard, P. Kinetics
of Grb2 Binding to Synapsin I, (1995) Society for Neuroscience, 25th.
Annual Meeting, San Diego, CA.
Sweeney, D., Zhou, Z., Martins, R., LeVine, H., Cheetham, J.J., Breslow,
J., Smith J., Greengard, P. and Gandy, S. Physiological Apolipoprotein
E e3 and e4 Isoforms Promote Fibrillogenesis of Aß (1-42) in a
Thioflavine T Assay, (1995) Society for Neuroscience, 25th. Annual Meeting,
San Diego, CA.
Hilfiker-Rothenfluh, S., Cheetham, J.J., Fienberg, A.A., Greengard,
P. and Czernik, A.J., Interaction of Calcium Calmodulin-Dependent Protein
Kinase II with Membranes: Studies with Purified Synaptic Vesicles and
Liposomes (1994) Society for Neuroscience, 24th. Annual Meeting, Miami,
Cheetham, J.J., Hilfiker-Rothenfluh, S., Czernik, A.J., Nairn, A.C.
and Greengard, P., Identification of Phospholipid Binding Sites in Synapsin
I Using Hydrophobic
Photoaffinity Labeling (1994) Society for Neuroscience, 24th. Annual
Meeting, Miami, FL.
Cheetham, J.J., Huang, H.-B., da Cruz e Silva, E.F., Kwon, Y., Czernik,
A.J., Nairn, A.C. and Greengard, P. Kinetics of Protein Phosphatase
1C Binding to Phospho-and Dephospho- DARRP 32, (1994) BIAsymposium,
Fourth Annual Meeting, Baltimore, MD.
Van Gorkom, L.C.M., Cheetham, J.J. and Epand, R.M., Ganglioside GD1a
Induces an Isotropic Phase in Phosphatidylethanolamines as Measured
by 31P NMR (1991) Biophysical Journal, 59, 313a.
Cheetham, J.J., Van Gorkom, L.C.M., Flanagan, T.D. and Epand, R.M.,
Bilayer Stabilizers Inhibit Sendai Virus Fusion at Neutral pH But Not
Acid-Induced Fusion of Influenza Virus (1991) Biophysical Journal, 59,
Epand, R.M., Cheetham, J.J., Epand, R.F., Peptide Models for the Membrane
Destabilizing Actions of Viral Fusion Proteins (1991) The Peptide-Protein
Bridge Conference, Toronto, Ontario, Canada.
Cheetham, J.J., Flanagan, T.D. and Epand, R.M., Inhibition of Virus
Fusion to Biological and Model Membranes by Bilayer Stabilizing Molecules
(1990) Biophysical Journal, 57, 491a.
Epand, R.M., Cheetham, J.J. and Bottega, R., Substances Which Affect
the Bilayer to Hexagonal Phase Transition Temperature and Their Effect
on Membrane Fusion (1988) Biochemistry, 27, 3083.
Cheetham, J.J., Epand, R.M. and Flanagan, T.D., Substances Which Stabilize
the Bilayer Phase of Membranes can Inhibit Membrane Fusion, (1988) FASEB
Summer Research Conference on Structure and Function of Membranes.
Epand, R.M., Cheetham, J.J., Bottega, R., Wachtel, E.J. and Bach, D.,
The Effects of Cholesterol and Epicholesterol on the Phase Behavior
of Phosphatidylethanolamines, (1988) FASEB Summer Research Conference
on Structure and Function of Membranes.
Non-Refereed Publications and Technical Documents:
Kumar, P., Cheetham, J.J., Vierula, J. (2000) A Survey of Non-living
Biotechnology R&D in Canada for The Canadian Space Agency. Contract
Cheetham, J.J. and McPhee, D. (1998) Efficient disruption of E.coli
using the EmulsiFlex C5, Avestin Inc. Technical Bulletin.
Cheetham, J.J., Stewart, A., Hurley, S., McPhee, D. (1998) High volume
disruption of three yeasts using the EmulsiFlex C160, Avestin Inc. Technical
Current and Previous Research Support
National Sciences and Engineering Research Council (NSERC)
Medical Research Council of Canada (Fellowship)
Anti-Oxidant Research Fund
American Alzheimer Society
Alberta Heritage Foundation
Journal of Biological Chemistry
Garland Scientific Publishing
Participation in Industrial Research and Development
I was involved in research leading to the development of a hydrophobic
biosensor chip which is now used to study protein-lipid and protein-protein
interactions with the BIAcore instrument from Pharmacia Biosensor, Piscataway,
NJ. I have also consulted for Neurogen Corp., Guildford, CT. on various
aspects or membrane protein biochemistry and purification and assay
development. I also worked with Avestin Inc., Ottawa, ON on the evaluation
of several different designs of extruders and emulsifiers, which are
used in the biotechnology industry for the production of liposomes and
the disruption of microorganisms. With Giles Santyr, we developed a
biocompatible emulsion for the transport of hyperpolarized xenon gas
to be used as a contrast reagent for magnetic resonance imaging.
Dr. Frank Dehne
Dr. Andrew Rau-Chaplin
Applications of parallel computing in bioinformatics.
Dr. Linda Johnston
Steacie Institute for Molecular Sciences, NRC
Atomic force and near field microscopy studies of protein-lipid
Other professional affiliations and responsibilities
1996-Present Member, Carleton Institute of Neuroscience
1996-Present Member, Ottawa-Carleton Institute of Biology
1996-Present Member, Carleton Institute of Biochemistry
1993-1996 Member, Science Outreach Program, Rockefeller University
1995-1996 Consultant, Pharmacia Biosensor, Piscataway, NJ
1994-1997 Consultant, Neurogen, Guildford, CT
1997-2001 Consultant, Avestin Inc., Ottawa, ON
2000-Present Member Pipers and Pipeband Society of Ontario (PPBSO).
Teaching Experience: Courses developed, organized and taught
61.5555* - Membrane Biochemistry
Developed and organized a graduate level course dealing with various
aspects of membrane biochemistry and biophysics. Average of 6 students/year,
graduate courses are not evaluated. Offered winter term, 1997, 98 and
99. Course Website: http://www.carleton.ca/~jcheetha/membrane
Biochemistry 4004 - Industrial Biochemistry
A course illustrating the application of biochemistry to the production
of biological compounds useful in nutrition, medicine, and the food
and chemical industries. The course also reviews the general strategies
for efficient production of these compounds by controlling the activities
of living cells or enzymes. This course makes extensive use of the world
wide web. 35 students/year. Overall evaluation: 1997/98 4.79
out of 5.001998/99 4.64 out of 5.00. Course Website: http://www.carleton.ca/~jcheetha/industrial
Biochemistry 4002 - Biomacromolecules
Biochemistry of polysaccharides, proteins and nucleic acids. Discussion
of experimental approaches to purification and conformational studies
of biomacromolecules, their interaction in solutions, function and regulation
of enzymes. Workshop sessions include discussion of experimental design
and interpretation, and solving of related numerical problems. Fourth
year biochemistry course on macromolecular structure and function. 35
students/year. Evaluation: 1997/98 4.53 out of 5.00,1998/99
4.43 out of 5.00. Course Website: http://www.carleton.ca/~jcheetha/macro
Biochemistry 4007 - Membrane Biochemistry
Biochemical and biophysical aspects of biomembrane structure and function.
Topics may include: membrane lipids and proteins, lipid polymorphism,
model membranes, liposomes, membrane biogenesis, the membrane cytoskeleton,
membrane trafficking, membrane fusion, exocytosis and signal transduction
across membranes. This course makes extensive use of electronic tools
for presentation of information. Course Website: http://www.carleton.ca/~jcheetha/membranes
Other teaching experience
Instructor, Carleton University Enrichment Program for High School
students, Carleton University, Ottawa, ON. Course title: Exploring the
Brain, May 1998 and May 1999. 20 students/year.
Department of Biology Liason Person with the Teaching and Learning
Centre, Carleton University.
1996-Present Judge, Ottawa Regional Science Fair
Faculty Advisor for Neuroscience Undergraduate Program 1996-2002.
Co-op Advisor for Biology, 1999-2002.
Mentor, Laboratory of Molecular and Cellular Neuroscience, The Rockefeller
University, New York, NY. May 1993-August 1996. Design of research projects
and supervision of graduate students and summer undergraduate research
Teaching Assistant, Faculty of Health Sciences, McMaster University,
Hamilton, Ont., Canada. September 1988 to December 1992.
Contributions to the Training of Highly Qualified Personnel
(see Lab Alumni)
Supervisory Committees (in last 4 years): 27
M.Sc. Students (in last 4 years): 4
B.Sc. Honours Thesis Students:
Graduate Thesis Examination Boards: 9 Ph.D. 17 M.Sc.
Ph.D. Comprehensive Examination Boards: 7
Integrated Science Student Supervisions: 12
Directed Studies Supervisions: 24
Honours and Awards
Teaching Achievement Award, Carleton University, Active: 2000. Total
Medical Research Council of Canada (MRC) Postdoctoral Fellowship. Active:
May 1993 to July 1996. Total award: $81,900.
National Sciences and Engineering Research Council of Canada (NSERC)
Postdoctoral Fellowship. Active: not activated due to acceptance of
MRC award. Total award: $76,446.
National Science and Engineering Research Council of Canada (NSERC)
Predoctoral Fellowship. Active: January 1990 to December 1992. Total
Ontario Graduate Student Fellowship. Active: not activated due to acceptance
of NSERC award. Total award: $38,650.
Medical Research Council of Canada (MRC) Predoctoral Fellowship. Active:
not activated due to acceptance of NSERC award. Total award: $42,836.
Biophysical Society Talbot Award. Active: 1990. Total Award: $400
McMaster University Graduate Student Fellowship. Active: September 1987
to December 1989. Total award: $30,482.
Selected Seminars by J.J. Cheetham
Multiple Sequence Alignment with Parallel Computing, High Performance
Computing Virtual Laboratory (HPCLV) Symposium, November, 2002.
Liposomes, Micelles and Emulsions as Models of Biological Membranes,
Steacie Institute for Molecular Sciences, National Research Council
of Canada, February 2000. Host: Dr. Keith Ingold.
Functions of Synapsins in the Presynaptic Nerve Terminal, Department
of Biology, University of Ottawa, October 1999. Host: Dr. Vance Trudeau
An Introduction to Protein Structure, Department of Computer Science,
Carleton University, August, 1999. Host: Dr. Frank Dehne.
Signal Transduction in the Presynaptic Nerve Terminal, Merck Inc. Rahway,
NJ, January, 1996.
Host: Dr. Andrew Howard
Selected Seminars by J.J. Cheetham (cont.)
Reconstitution of Synaptic Vesicle Proteins, Neurogen Inc., Guildford,
CT, December, 1995.
Liposomes and Biosensors, Pharmacia Biosensor, Piscataway, NJ, October,
1994. Host: William Farley.
Bilayer Stabilization and Membrane Fusion, The Liposome Company, Princeton,
NJ, August, 1993.
Host: Dr. Andrew Janoff
Viral Membrane Fusion: Inhibition by Bilayer Stabilizers, The Rockefeller
University, New York, NY, November 1992. Host: Dr. Paul Greengard.
Inhibition of Viral Membrane Fusion with Bilayer Stabilizers, State
University of New York at Buffalo, Buffalo, NY, December 1992. Host:
Dr. Thomas Flanagan.
2000-2002 Chair, Computational Sciences Committee. Oversee implementation
of the undergraduate programs in Computational Sciences.
1999-2000 Member for Biology, Presidential Task Force, Building a Research-Intensive
of Carleton University's Task Force on Research
1999-2000 Member for Biology, College of Natural Sciences, Review Committee.
Review operation and governance of the College of Natural Sciences.
2000-2002 Biochemistry and Biotechnology Co-op Advisor.
1998-2000 Biology member, Faculty of Science Computing Policy Committee.
Responsible for information gathering, formulating and writing the Information
Technology Strategic Plan for the Biology Department.
1998-1999 Member, Biology Curriculum Committee. Responsible for discussing,
and implementing changes to the undergraduate calendar that are in keeping
changes in faculty numbers and expertise.
1998 Chair, Biology Tenure and Promotion Committee. Responsible for
chairing meetings, organizing materials and letters for the promotion
1997-1998 Member, Search Committee for Biology. Responsible for evaluating
applications, and interviewing candidates.
1997-1998 Coordinator; Biology Department Seminar Series. Responsible
for organizing a weekly seminar series with invited speakers.
1996-Present Member for Biology, B.A. Council. Responsible for writing
description for the Bachelor of Arts degrees in Biology to bring them
agreement with the revised BA Template and for dealing with any other
in the B.A. or B.Sc. Programs that affect the B.A. programs in Biology.
1997-1998 Member for Biology, B.A. Council, First Year Seminar Course
Participated in the design and implemenation of the First Year Seminar
for BA students.
1998-Present Member for Biology, B.A. Council, First Year Seminar Evaluation
Responsible for evaluation of the First Year Seminar Program.
1996-Present Webmaster, Carleton
Institute of Biochemistry. Design and maintenance of the Institute
of Biochemistry web pages.
1996-2001 Member, Carleton Biomedical Research Committee. Responsible
designing and having printed brochures to promote Carleton research
in the areas
of Medical Physics, Neuroscience and Biotechnology.
1997-1998 Chair, Biochemistry Bioinformatics Committee. Organized meetings
faculty members. Contributed suggestions to ITSP contributions.
1996-1998 Member, Biology Recruitment and Retention Committee. Organized
increase student recruitment into Biology Programs and to increase retention
1996 Member of Stephen Jay Gould Lecture Organizing Committee (with
and M. Smith).