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FUNCTIONAL METABOLISM: REGULATION AND ADAPTATION Editor: Kenneth B. Storey Wiley-Liss, NY, 2004, 594p. Order from Wiley-Liss Order from Amazon.com SAMPLE CHAPTER Reviews of the book in: Journal of Experimental Biology -- Clinical Biochemistry Biochemistry and Molecular Biology Education -- Estreams American Journal of Human Biology -- Annals of Biomedical Engineering Comparative Biochemistry and Physiology B
Chapter 1. Principles of Metabolic Control	William C. Plaxton, Queen’s University, Kingston
Chapter 2. Enzymes: the Basis of Catalysis	Stephen P.J. Brooks, Health Canada, Ottawa
Chapter 3. Enzymes in the Cell: What’s Really Going On?	Stephen P.J. Brooks, Health Canada, Ottawa
Chapter 4. Signal Transduction Pathways and the Control of Cellular Responses to External Stimuli	Justin A. MacDonald, University of Calgary, Calgary
Chapter 5. Tyrosine Phosphorylation and the Control of Cellular Information	Justin A. MacDonald, University of Calgary, Calgary
Chapter 6. Control of Transcription in Eukaryotic Cells	William G. Willmore, Carleton University, Ottawa
Chapter 7. Translational Controls and Protein Synthesis in Eukaryotic Cells.	William G. Willmore, Carleton University, Ottawa
Chapter 8. The Mitochondria: Powerhouse of the Cell	Kyra J. Cowan, Epitomics, Inc., San Francisco
Chapter 9. Human Energy Metabolism in Health and Disease	Steven C. Greenway, Hospital for Sick Children, Toronto
Chapter 10. Hormones in Human Metabolism and Disease	Steven C. Greenway, Hospital for Sick Children, Toronto
Chapter 11. Skeletal Muscle Metabolism and Plasticity	Denis R. Joanisse, Laval University, Quebec
Chapter 12. Oxygen in Biology and Biochemistry: Role of Free Radicals	Marcelo Hermes-Lima, University of Brasilia, Brasilia
Chapter 13. Oxidative Stress and Medical Sciences	Marcelo Hermes-Lima, University of Brasilia, Brasilia
Chapter 14. Biochemical Adaptation	Kenneth B. Storey, Carleton University, Ottawa
Chapter 15. Oxygen Limitation and Metabolic Rate Depression	Kenneth B. Storey and Janet M. Storey, Carleton University, Ottawa
Chapter 16. Mammalian Hibernation: Biochemical Adaptation and Gene Expression	Kenneth B. Storey and Janet M. Storey, Carleton University, Ottawa
Chapter 17. Cold Hardiness and Freeze Tolerance	Janet M. Storey and Kenneth B. Storey, Carleton University, Ottawa
Chapter 18. Aspects of Blood Cell Biochemistry: Erythrocytes, Platelets and Stem Cells	Jean E. Grundy, Health Canada, Ottawa
Chapter 19. Organ Preservation for Transplantation	Thomas A. Churchill, University of Alberta, Edmonton
Chapter 20. Metabolic Evolution and the Origin of Life	Tolga Bilgen, University of Washington, Seattle

Summary In the post-genome era, questions concerning gene products (proteins), enzymes, and metabolism are returning to the forefront of life science research. Genetic information on its own does not fully account for an enzyme’s kinetic and regulatory properties or for the behaviour of the enzymes within its particular cellular milieu. Many questions remain about the regulation, integration and adaptation of metabolism and these have led to a resurgence of interest in protein, enzymological, and metabolic research for understanding biological processes. Functional Metabolism: Regulation and Adaptation provides a comprehensive survey of metabolism, including an in-depth examination of the regulation of carbohydrates, lipids, and amino acids, and approaches including enzyme regulation, signal transduction, and control of transcription and translation. The text has major coverage of oxidative stress and antioxidant biochemistry – including basic molecular concepts, damage and repair systems, and cellular and whole body consequences of free radicals in human health and disease. The contributors—an internationally recognized group of researchers—also cover: The metabolic basis of human conditions: diabetes, obesity, blood disorders Novel perspectives on animal biochemical adaptation to environmental stress Application of metabolic knowledge to developments in organ preservation and understanding the origin of life From the basics of metabolic regulation and adaptation to the latest relevant advances in the genetic, proteomic and enzymatic basis of how cells regulate their functions, Functional Metabolism: Regulation and Adaptation offers the most exhaustive treatment of the subject currently available. It is an essential text for students and practitioners in biochemistry, cell/molecular biology, and biomedicine.

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