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FUNCTIONAL METABOLISM:
REGULATION AND ADAPTATION

Editor: Kenneth B. Storey

Wiley-Liss, NY,  2004,  594p.  

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Reviews of the book in:

Journal of Experimental Biology       --     Clinical Biochemistry

Biochemistry and Molecular Biology Education          --          Estreams

American Journal of Human Biology    --      Annals of Biomedical Engineering

Comparative Biochemistry and Physiology B

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Chapter 1. Principles of Metabolic Control

William C. Plaxton, Queen’s University, Kingston

Chapter 2. Enzymes: the Basis of Catalysis

Stephen P.J. Brooks, Health Canada, Ottawa

Chapter 3. Enzymes in the Cell: What’s Really Going On?

Stephen P.J. Brooks, Health Canada, Ottawa

Chapter 4. Signal Transduction Pathways and the Control of Cellular Responses to External Stimuli

Justin A. MacDonald, University of Calgary, Calgary

Chapter 5. Tyrosine Phosphorylation and the Control of Cellular Information

Justin A. MacDonald, University of Calgary, Calgary

Chapter 6. Control of Transcription in Eukaryotic Cells

William G. Willmore, Carleton University, Ottawa

Chapter 7. Translational Controls and Protein Synthesis in Eukaryotic Cells.

William G. Willmore, Carleton University, Ottawa

Chapter 8. The Mitochondria: Powerhouse of the Cell

Kyra J. Cowan, Epitomics, Inc., San Francisco

Chapter 9. Human Energy Metabolism in Health and Disease

Steven C. Greenway, Hospital for Sick Children, Toronto

Chapter 10. Hormones in Human Metabolism and Disease

Steven C. Greenway, Hospital for Sick Children, Toronto

Chapter 11. Skeletal Muscle Metabolism and Plasticity

Denis R. Joanisse, Laval University, Quebec

Chapter 12. Oxygen in Biology and Biochemistry: Role of Free Radicals

Marcelo Hermes-Lima, University of Brasilia, Brasilia

Chapter 13. Oxidative Stress and Medical Sciences

Marcelo Hermes-Lima, University of Brasilia, Brasilia

Chapter 14. Biochemical Adaptation

Kenneth B. Storey, Carleton University, Ottawa

Chapter 15. Oxygen Limitation and Metabolic Rate Depression

Kenneth B. Storey and Janet M. Storey, Carleton University, Ottawa

Chapter 16. Mammalian Hibernation: Biochemical Adaptation and Gene Expression

Kenneth B. Storey and Janet M. Storey, Carleton University, Ottawa

Chapter 17. Cold Hardiness and Freeze Tolerance

Janet M. Storey and Kenneth B. Storey, Carleton University, Ottawa

Chapter 18. Aspects of Blood Cell Biochemistry: Erythrocytes, Platelets and Stem Cells

Jean E. Grundy, Health Canada, Ottawa

Chapter 19. Organ Preservation for Transplantation

Thomas A. Churchill, University of Alberta, Edmonton

Chapter 20. Metabolic Evolution and the Origin of Life

Tolga Bilgen, University of Washington, Seattle

    Summary In the post-genome era, questions concerning gene products (proteins), enzymes, and metabolism are returning to the forefront of life science research. Genetic information on its own does not fully account for an enzyme’s kinetic and regulatory properties or for the behaviour of the enzymes within its particular cellular milieu. Many questions remain about the regulation, integration and adaptation of metabolism and these have led to a resurgence of interest in protein, enzymological, and metabolic research for understanding biological processes.   Functional Metabolism: Regulation and Adaptation provides a comprehensive survey of metabolism, including an in-depth examination of the regulation of carbohydrates, lipids, and amino acids, and approaches including enzyme regulation, signal transduction, and control of transcription and translation. The text has major coverage of oxidative stress and antioxidant biochemistry – including basic molecular concepts, damage and repair systems, and cellular and whole body consequences of free radicals in human health and disease. The contributors—an internationally recognized group of researchers—also cover:   The metabolic basis of human conditions: diabetes, obesity, blood disorders Novel perspectives on animal biochemical adaptation to environmental stress Application of metabolic knowledge to developments in organ preservation and understanding the origin of life   From the basics of metabolic regulation and adaptation to the latest relevant advances in the genetic, proteomic and enzymatic basis of how cells regulate their functions, Functional Metabolism: Regulation and Adaptation offers the most exhaustive treatment of the subject currently available. It is an essential text for students and practitioners in biochemistry, cell/molecular biology, and biomedicine.  

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